The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease
Identifieur interne : 000F32 ( Main/Exploration ); précédent : 000F31; suivant : 000F33The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease
Auteurs : Li Cao [République populaire de Chine] ; Ting Zhang [République populaire de Chine] ; Qin Xiao [République populaire de Chine] ; Ying Wang [République populaire de Chine] ; Li Bai [République populaire de Chine] ; Guo Qiang Lu [République populaire de Chine] ; Jian Fang Ma [République populaire de Chine] ; Jing Zhang [République populaire de Chine] ; Jian Qing Ding [République populaire de Chine] ; Sheng Di Chen [République populaire de Chine]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
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Abstract
We conducted a case–control study to determine the prevalence of the LRRK2 Gly2385Arg variant in patients with Parkinson's disease in Han population in mainland China. Heterozygous LRRK2 Gly2385Arg variant was identified in 14 of 235 patients with Parkinson's disease (5.69%), but not in 214 unrelated healthy controls. Multivariate analysis indicated the frequency of Gly2385Arg variant in the female patients with early age at onset is higher than their male counterparts. The founder haplotype analysis showed the variant carriers shared the same founder. Clinically, the LRRK2 Gly2385Arg carriers presented with classical Parkinson's disease symptoms. Our study indicates that the LRRK2 Gly2385Arg variant is a potential ethnic‐specific genetic risk factor of Parkinson's disease within Chinese Han ethnicity. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21763
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Li" sort="Bai, Li" uniqKey="Bai L" first="Li" last="Bai">Li Bai</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Guo Qiang" sort="Lu, Guo Qiang" uniqKey="Lu G" first="Guo Qiang" last="Lu">Guo Qiang Lu</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Jian Fang" sort="Ma, Jian Fang" uniqKey="Ma J" first="Jian Fang" last="Ma">Jian Fang Ma</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) and Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Jian Qing" sort="Ding, Jian Qing" uniqKey="Ding J" first="Jian Qing" last="Ding">Jian Qing Ding</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) and Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Sheng Di" sort="Chen, Sheng 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-12-15">2007-12-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2439">2439</biblScope><biblScope unit="page" to="2443">2443</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0B981E90432C91BD975B5183F6677473D9521879</idno><idno type="DOI">10.1002/mds.21763</idno><idno type="ArticleID">MDS21763</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>China</term><term>Gly2385Arg</term><term>Han ethnicity</term><term>LRRK2</term><term>Parkinson's disease</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a case–control study to determine the prevalence of the LRRK2 Gly2385Arg variant in patients with Parkinson's disease in Han population in mainland China. Heterozygous LRRK2 Gly2385Arg variant was identified in 14 of 235 patients with Parkinson's disease (5.69%), but not in 214 unrelated healthy controls. Multivariate analysis indicated the frequency of Gly2385Arg variant in the female patients with early age at onset is higher than their male counterparts. The founder haplotype analysis showed the variant carriers shared the same founder. Clinically, the LRRK2 Gly2385Arg carriers presented with classical Parkinson's disease symptoms. Our study indicates that the LRRK2 Gly2385Arg variant is a potential ethnic‐specific genetic risk factor of Parkinson's disease within Chinese Han ethnicity. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cao, Li" sort="Cao, Li" uniqKey="Cao L" first="Li" last="Cao">Li Cao</name></noRegion><name sortKey="Bai, Li" sort="Bai, Li" uniqKey="Bai L" first="Li" last="Bai">Li Bai</name><name sortKey="Chen, Sheng Di" sort="Chen, Sheng Di" uniqKey="Chen S" first="Sheng Di" last="Chen">Sheng Di Chen</name><name sortKey="Chen, Sheng Di" sort="Chen, Sheng Di" uniqKey="Chen S" first="Sheng Di" last="Chen">Sheng Di Chen</name><name sortKey="Ding, Jian Qing" sort="Ding, Jian Qing" uniqKey="Ding J" first="Jian Qing" last="Ding">Jian Qing Ding</name><name sortKey="Ding, Jian Qing" sort="Ding, Jian Qing" uniqKey="Ding J" first="Jian Qing" last="Ding">Jian Qing Ding</name><name sortKey="Lu, Guo Qiang" sort="Lu, Guo Qiang" uniqKey="Lu G" first="Guo Qiang" last="Lu">Guo Qiang Lu</name><name sortKey="Ma, Jian Fang" sort="Ma, Jian Fang" uniqKey="Ma J" first="Jian Fang" last="Ma">Jian Fang Ma</name><name sortKey="Wang, Ying" sort="Wang, Ying" uniqKey="Wang Y" first="Ying" last="Wang">Ying Wang</name><name sortKey="Xiao, Qin" sort="Xiao, Qin" uniqKey="Xiao Q" first="Qin" last="Xiao">Qin Xiao</name><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><name sortKey="Zhang, Ting" sort="Zhang, Ting" uniqKey="Zhang T" first="Ting" last="Zhang">Ting Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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